分類: 蚊媒疾病新知
環保署公告新增列管沃爾巴克氏菌為應用於防制環境衛生病媒之微生物製劑
提供單位：行政院環境保護署毒物及化學物質局 發布日期：2018.10.17網址：https://en…
【科技新知】Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs
Recent Zika virus (ZIKV) outbreaks have highlighted the necessity for development of novel vector control strategies to combat arboviral transmission, including genetic versions of the sterile insect technique, artificial infection with Wolbachia to reduce population size and/or vectoring competency, and gene drive-based methods. Here, we describe the development of mosquitoes synthetically engineered to impede vector competence to ZIKV. We demonstrate that a polycistronic cluster of engineered synthetic small RNAs targeting ZIKV is expressed and fully processed in Aedes aegypti, ensuring the formation of mature synthetic small RNAs in the midgut where ZIKV resides in the early stages of infection. Critically, we demonstrate that engineered Ae. aegypti mosquitoes harboring the anti-ZIKV transgene have significantly reduced viral infection, dissemination, and transmission rates of ZIKV. Taken together, these compelling results provide a promising path forward for development of effective genetic-based ZIKV control strategies, which could potentially be extended to curtail other arboviruses.
當我們伸手拍打蚊子時，它們學會少招惹你
即使無法將昆蟲搗碎成血腥的果肉，但一巴掌的震動足以讓蚊子放棄誘人的血液香氣。科學家們為了證明昆蟲能記…
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環保署公告新增列管沃爾巴克氏菌為應用於防制環境衛生病媒之微生物製劑
提供單位：行政院環境保護署毒物及化學物質局 發布日期：2018.10.17網址：https://en…
【科技新知】Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs
Recent Zika virus (ZIKV) outbreaks have highlighted the necessity for development of novel vector control strategies to combat arboviral transmission, including genetic versions of the sterile insect technique, artificial infection with Wolbachia to reduce population size and/or vectoring competency, and gene drive-based methods. Here, we describe the development of mosquitoes synthetically engineered to impede vector competence to ZIKV. We demonstrate that a polycistronic cluster of engineered synthetic small RNAs targeting ZIKV is expressed and fully processed in Aedes aegypti, ensuring the formation of mature synthetic small RNAs in the midgut where ZIKV resides in the early stages of infection. Critically, we demonstrate that engineered Ae. aegypti mosquitoes harboring the anti-ZIKV transgene have significantly reduced viral infection, dissemination, and transmission rates of ZIKV. Taken together, these compelling results provide a promising path forward for development of effective genetic-based ZIKV control strategies, which could potentially be extended to curtail other arboviruses.
當我們伸手拍打蚊子時，它們學會少招惹你
即使無法將昆蟲搗碎成血腥的果肉，但一巴掌的震動足以讓蚊子放棄誘人的血液香氣。科學家們為了證明昆蟲能記…